I have had a couple of lumps appear on the palm of my hand about 9 months ago.  Now I have 3 more appearing.  They seem to be opposite the knuckle joints, and are quite sore and tight.  Wish I knew what they are.

Greetings,

A growing number of lumps on the palm of the hand often means Dupuytren contracture, especially when they are in the fleshy part of the palm, not over the main joints, and you cannot account for trauma or abuse that might cause callus buildup.   While this is often the case, it cannot be said for sure until you have had a doctor examine you to make an accurate diagnosis.