Prescription drugs indirectly related to Dupuytren contracture
A Dupuytren cause could be related to drugs. As usual, there is controversy about drugs causing or contributing to Dupuytren’s contracture. However, because there is controversy and unknows in most areas of Dupuytren’s contracture, we speculate.
Even the cause of Dupuytren’s contracture remains unknown. Age, genetic predisposition, and liver cirrhosis related to alcoholism, have the strongest statistical and clinical support as a cause of DC. Interestingly, people think of trauma or injury most often as the cause of Dupuytren’s contracture. Perhaps this is because trauma, cuts and surgery lead to excess scar formation. And DC looks like heavy scar formation. Regardless, a person with Dupuytren’s contracture should focus about avoiding or reducing exposure to those causes of DC that are avoidable or at least controllable. Among them, there is statistical evidence that a Dupuytren cause could be related to drugs.
Drugs open the gate to DC when we are weak
For those who already have age (over 50), gender (male), genetic predisposition and liver disease in their history working against them, it is wise to pay close attention to other causes that are controllable. For example, prescription drug use. One side effect of these prescription drugs is to suppress or reduce the immune defense response of the body. Thus, with a weakened immune system, and liver disease due to drug toxicity, there is less ability to prevent development of Dupuytren contracture.
While no single drug or drug family has been implicated in causing Dupuytren contracture, many drugs have the potential. Prolonged use of a potent drug could initiate DC via the indirect mechanism by causing liver disease and cirrhosis usually associated with alcoholism. Bottom line, many drugs stress and injure the liver, and this is statistically important in causing Dupuytren’s contracture.
Drugs to keep in mind
As a general guideline, this list is provided to demonstrate a Dupuytren cause could be related to drugs because they all affect the liver, some more and some less. It is all about the connection between liver damage and Dupuytren’s contracture.
Drugs that may cause acute dose-dependent liver damage
- salicylates (doses over 2 grams daily)
Drugs that may cause acute dose-independent liver damage
- tricyclic antidepressants
- valproic acid
Bottom line on Dupuytren cause could be related to drugs
In conclusion, these listed drugs have side effects. They can complicate the problem of someone who is already sick. Use all drugs with caution and discretion. But if you have Dupuytren’s contracture, use these drugs with great caution. Talk to your doctor about using the safest drug possible for whatever problem you might have.
If you are male, over 50, with a family history of Dupuytren’s contracture, or a history of liver cirrhosis or heavy alcohol consumption, recognize these drugs pose a danger to you. Your particular Dupuytren cause could be related to drugs on this list. Possibly, you could be stressing your liver and putting yourself at further risk of worsening and accelerating your Dupuytren problem. For this reason, speak to your doctor if you are taking any of the above drugs. Ask about changing or reducing medication.
Also, consider using the safe and direct DCI Dupuytren contracture treatment option. When people use the DCI large plan, we get 8-10 reports of moderate to marked improvement of DC, for every one report of failure.