Why is Neprinol not in any Dupuytren treatment plan?

Dear Dr. Herazy,

I have had Dupuytren contracture in both hands for almost six years and they are slowly worsening, maybe the right hand more than the left. It is getting difficult to dress and do other common daily activities that i used to take for granted. My doctor said I should have surgery but I am not ready to take the risks that I read about when I investigate all the bad things that can happen.

After reading your website I see that you have some good ideas that appeal to my logical way of thinking. But when I read about the three Dupuytren treatment plans I notice that Neprinol is not listed in any of them. I have read many good things about Neprinol and wonder why it is not included, but you do include Fibrozym and Nattokinase. I want to place an order for either the medium or large size plan but I want to get this explained before placing my first order. Can you please clear this up for me?

Thank you in advance,


Greetings Vanessa,

Neprinol is not included in the DCI Small, Medium or Large Plans for two reasons:

1.  Neprinol is more powerful than Fibrozym and Nattokinase 1500.  It contains the same enzymes as Fibrozym and Nattokinase 1500 – at perhaps 10-12 times greater bioactivity.  It also contains different kinds of enzymes that are not found in Fibrozym and Nattokinase 1500.  this makes Neprinol more concentrated and with a greater variety of enzymes than these other products.  Therefore, based on almost ten years experience working with Dupuytren contracture I learned it is better to start treatment with the less intense and concentrated enzymes of Fibrozym and Nattokinase 1500 to get accustomed to the action of these enzymes; it is easier on the body and people have less intestinal upset (diarrhea) this way.   When you re-order the 1st or 2nd time you can then slowly introduce Neprinol into your treatment plan.

2.  Cost.  Because the bottle of Neprinol contains 300 capsules of more powerful and concentrated enzymes, as compared to 100 capsules in the other products, Neprinol costs more.  Therefore, many of our customers appreciate this way of keeping costs down when getting started.  The first order is the most expensive, and this is appreciated by anyone who is just starting and wants to how the suggested Dupuytren treatment plans work.

I suggest after being on your plan for a few weeks or few months, or whenever you are comfortable adding Neprinol to your plan, that you do so.  Many people will later use Neprinol as the primary source of systemic enzymes in their plan, but also keep a few Nattokinase 1500 and Fibrozym in their plans as secondary or minor sources of systemic enzymes.

Dupuytrens is a tough and terrible thing.  It takes dedication and persistence to overcome it.   I have worked with many who have had their problem longer than yours, and have done quite well.  It is never easy to overcome, but always worthwhile.

The biggest advantage in ordering your therapy products from DCI is that we provide a high level of service and background information specific to Dupuytren contracture that you will not receive from anyone else.   Just try to call one of those internet vitamin sellers and ask a question, let alone get specific information about treating Dupuytren contracture.  It cannot be done.    Each product you order from PDI comes with all the information you will need to you it correctly to treat your DC.

Please let me know if I can assist your recovery in any way.  Good luck to you.


2 thoughts on “Why is Neprinol not in any Dupuytren treatment plan?

  1. Laura Argo says:

    Dear Dr. Herazy,

    I took Levaquin in 2009 with devastating results and I am convinced the antibiotic is the reason I have Interstitial Cystitis, IBS, Esophagitis with GERD, and possible SIBO from low HCl. I eat a naturopathic diet of organic chicken stock and boiled chicken and cooked leafy vegetables that is helping me to make HCl for digestion. I take Quercetin with Bromelain for IC, MSM in a liquid that also had glucosamine condroitin. It is working for my bladder but my bladder is very sensitive to certain foods and I am unable to take the liquid multivitamin I used to take. This week I had a milder reaction to a Z-pack antibiotic but it also reactivated the crawling, burning nerve pain especially over my central back area and forearms. It has increased digestion problems so I am on a very strict diet to overcome the burning esophagus. I have trouble swallowing pills and I am allergic to all antibiotics.

    Late last year, I noticed what I thought were raised tendons on my palms. There are three on each palm and the left hand case is more prominent. It looks like Dupuytren’s contracture. IC is said to have the same mast cells as Dupuytren’s.

    What liquids or small capsules do you have that can reduced the inflammatiuon of Dupuytren’s contracture while I am in the early stages. After reading about DSMO treatment on your website I’d also be interested to know about possible side effects and safety. Anything that irritates the stomach and causes reflux or diarreah are ill advised. Also acidic things could trigger bladder spasms.

    I hope you can shed some light on this dilemma before I order. Thank you for the information you have provided. This is my first day of hearing about what is on my hand and its connection to IC so I am rather unerved to find I have yet another health issue. I am sixty one years old.

    Sincerely, Laura Argo

  2. Dr.Herazy says:

    Greetings Laura,

    So sorry to hear of your strong and widespread drug side effects to Levaquin; it can be a bad one. More and more I hear of people who have developed Dupuytren’s contracture after taking Levaquin.

    As far as Alternative Medicine treatment of Dupuytren’s contracture, all I can say is it would be a good idea to spend some time on the DCI website learning how we suggest it should be done; all the information is already here for you to read and learn. Start with the large yellow link for the New Customer in the upper right area of he homepage. Good Luck with your DC. TRH

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