Can Hepatitis C cause lumps in the palm of the hand?

Can Hepatitis C, which I have had for 35 years, cause lumps in the palm of the hand?



Yes and no.

Yes, there is some evidence that suggest a statistical association between liver disease such as hepatitis and Dupuytren’s contracture, which as you know is associated with palm lumps and bumps.  But, not all people who have liver disease develop Dupuytrens, and not all people with Dupuytrens have liver disease, but some studies show a tendency for those with Dupuytrens to have a higher than average occurrence of liver problems for reasons that have not been clearly defined. 

No, hepatitis C dos not cause palm lumps.   TRH     


2 thoughts on “Can Hepatitis C cause lumps in the palm of the hand?

  1. Shirl says:

    Along this line of thought …

    Beside Dupuytren’s contracture of the hand and penis I believe DC can present in certain people (not all) diagnosed with liver fibrosis/cirrhosis. My question is that, aside from the copper product, which could be harmful to a decompensated liver, in your opinion would Neprinol be safe and helpful in addressing the uncontrollable manufacture of myofibroblasts (TGF-B1) that produce fibrogenesis in the liver/spleen?

  2. Dr.Herazy says:

    Greetings again Shirl,

    The fibromatosis affecting the hand is known as Dupuytren’s contracture, of the penis is Peyronie’s disease, and of the plantar foot is Ledderhose disease.

    The current concept is that systemic fibrinolytic enzymes, such as Neprinol, degrade the fibrin and collagen in situ, or while in place as a lesion and not during its manufacture (TGF-B1). Much research and controlled studies are needed to more closely define this process. The manufacturers do not have the clinical, technical or financial wherewithal to do this, and the research community does not have the interest. TRH

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