Dupuytren Cause Could Be Related to Drugs

Prescriptions drugs indirectly related to Dupuytren cause

The cause of Dupuytren contracture remains unknown, but is logically most often attributed to trauma to the hand.  However, it is age, genetic predisposition and liver cirrhosis related to alcoholism that are more strongly associated with the causation of this problem.  While trauma (either small repeated injuries as with a bricklayer, or a large one-time injury as with a fall or crushing trauma), can be implicated in some cases, its relationship is not statistically significant.

Refuting the idea that trauma is a casual factor for Dupuytren hand and finger contracture are a few simple observations.  It has been frequently noted that the hand that actually develops the hand lump of Dupuytren is very often the side opposite the side of handedness; it is assumed that right handed workers would sustain more trauma to their right hand, yet these right handed people often develop a Dupuytren contracture on the opposite or left hand, and vice versa.    Also, it has been observed that people who have sustained significant past trauma to a hand will later develop a bump on palm of the hand on the opposite side to which significant trauma cannot be recalled.

In those who already have age, gender (male), genetic predisposition and liver disease in their history working against them, it would be wise for this group of people to pay close attention to drug intake that might potentially overwhelm the immune defense response to allow development of Dupuytren contracture.

While no single drug or drug family has been implicated in causing Dupuytren hand contracture, there is a potential for many drugs to initiate this problem via the indirect mechanism by causing liver disease and cirrhosis usually associated with alcoholism.

As a general guideline, this list is provided to demonstrate some of the many drugs that affect the liver to one degree or another.

Drugs that may cause acute dose-dependent liver damage

  • acetaminophen
  • salicylates (doses over 2 grams daily)

Drugs that may cause acute dose-independent liver damage

  • acebutolol
  • labetalol
  • quinine
  • indomethacin
  • phenylbutazone
  • allopurinol
  • isoniazid
  • phenytoin
  • lisinopril
  • atenolol
  • ketoconazole
    • piroxicam
      ·  carbamazepine
      ·  cimetidine
    • maprotiline
    • pyrazinamide
    • dantrolene
    • metoprolol
    • quinidine
      • diclofenac
        ·  probenecid
      • cimetidine
      • maprotiline
      • pyrazinamide
      • dantrolene
      • metoprolol
      • quinidine
        • diclofenac
          ·  penecillins
        • mianserin
          ·  phenelzine
        • tricyclic antidepressants
        • halothane
        • phenindione
        • valproic acid
        • ibuprofen
        • phenobarbital
          • verapamil
  • ethionamide

The bottom line concerning all these drugs is that every one of them has side-effects and ways of complicating the problem of someone who is already sick.  Drugs should be used with great reserve and discretion, and avoided if at all possible.

If you are man in a higher age, with a history of Dupuytren contracture in your family and you have a history of cirrhosis or heavy alcohol consumption, you would be wise to speak to your doctor if you are taking any of the above drugs because you could be stressing our liver and putting yourself at further risk of Dupuytren contracture.

Once Dupuytren contracture is present and someone learns that there is no known medical treatment available other than risky surgery, consider using Alternative Medicine as a Dupuytren contracture treatment option.  This is an option that the Dupuytren Contracture Institute has researched and developed since 2002, with considerable success.

6 thoughts on “Dupuytren Cause Could Be Related to Drugs

  1. DR GHORPADE says:

    Recently came across a case of mixed anxiety and depression with epilepsy who reported Duptries contraction due to long term valproate ingestion. If you can give references with regards to this it would be interesting to go through it.

  2. Shan MacPherson says:

    I acquired aggressive Dupuytren’s contracture following a 4 1/2 week course of ciprofloxacin, and wonder if there are other recorded cases of this.

  3. 88TRH88 says:

    Greetings Shan,

    Yes, there is a lot of evidence correlating Ciprofloxacin use and Dupuytren’s contracture. As examples: 1. Several published studies exist. 2. Possible side effect of Dupuytren’s contracture is mentioned in the literature specifically about Ciprofloxacin. 3. I have communicated with many people who state their Dupuytren’s contracture began after using Ciprofloxacin. Any knowledgeable doctor who prescribes this drug should be aware of the many side effects of Ciprofloxacin, including DC.

    Considering your last name, and the genetic predisposition it suggests, I believe you are at a greater risk of developing Dupuytren’s contracture as a result of taking Ciprofloxacin.

    Please be very careful about considering surgery to correct your Dupuytren’s contracture, since I believe your hereditary predisposition would make you more likely to have an unfavorable outcome. The same is true for using a Xiaflex injection series, which is very similar to surgery in that massive tissue destruction is involved. TRH

  4. Barbara says:

    I fractured my left wrist 5 months prior to developing nodules on the left palm. I had surgical repair of trigger finger on my right first & third digits. About 2 months later developed nodules to my right palm. Is this likely Dupuytren’s contracture & was it caused by the trauma of the fracture & surgery? If yes, what is the best treatment to prevent contractions?

  5. Dr. Herazy says:

    Greetings Barbara,

    For a definite and clear answer to your question you must be examined by a doctor who has knowledge and experience with hand problems. However, based on your history of fracture and subsequent hand surgery for trigger finger and your report of nodules on your palm, there is a very strong likelihood you are already in the early stages of Dupuytren’s contracture. It is possible I am wrong, but not likely.

    You are wise to want to start treatment early; this will provide best results. As far as the best way to proceed, it has long been the position of DCI that best results are achieved by using the DCI large plan. You do not want to give this problem an opportunity to develop further, so aggressive treatment is warranted. As I mention throughout this website, 8-10 of our therapy users on the large DCI treatment plan report moderate to marked reduction of the palm nodule and cord for every one report of failure. Pretty good results for such a safe form of Dupuytren’s contracture treatment. Full instructions for using the large plan come with each order.

    You most definitely would be wise to avoid any further trauma (surgery) to your hand since this will only stimulate more DC development. And as you can tell by the answers given to our readers, as well as how quickly we reply to questions, we take very good care of our our DCI users.

    Let me know if you have any questions. TRH

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