Dupuytren Contacture and DMSO
DMSO (Dimethyl Sulfoxide) to treat Dupuytren’s contracture
Dupuytrens contracture is commonly treated in Alternative Medicine using DMSO in combination with vitamin E and an ionic copper solution
DMSO is one of the stars of any broad-base Dupuytrens contracture treatment plan. It has some great science and research behind it, and it just makes a lot of sense to apply such an effective product directly to the problem area of the hand. In addition, DMSO can be used to enhance absorption of copper and vitamin E into the scar tissue area – both of which are also critically important to any Dupuytrens contracture program.
Dimethyl sulfoxide, better known as DMSO, is a colorless and slightly oily liquid. It is a by-product of the paper manufacturing process, and is still used primarily as an industrial solvent. Stanley W. Jacob, MD first reported the medicinal effects of DMSO in 1964.
By the late 1960s it was known as a popular wonder drug because of its potential as a therapeutic agent and a pharmaceutical solvent, reported to be useful for a variety of problems ranging from arthritis to mental retardation. It has been used in treatment of Dupuytrens contracture and Peyronie’s disease for many years.
Most therapeutic benefits of DMSO are documented in connective tissue diseases in particular, such as Dupuytrens contracture, scleroderma, rheumatoid and osteoarthritis, and muscle injury.(1-3) The AMA is among this group of supporters of DMSO for these applications. Multiple research suggests that DMSO applied over the afflicted region may soften the abnormal connective tissue associated with disorders such as Dupuytren’s contracture of the hand, Peyronie’s disease, scleroderma and keloids.(4)
Each of these four conditions is similar, in that they share a thickening and hardening of tissue, and excess collagen and fibrous tissue deposits. As you read these therapy sections, you will notice scleroderma and Dupuytren’s contracture are often mentioned with Peyronie’s disease . This is because of the similarity of abnormal tissue hardening which occurs in each. Suffice it to mention that both of these conditions are connective tissue disorders of unknown cause, with similar track records of poor and variable treatment outcomes.
Technique for using DMSO for Dupuytrens
First apply one or more primary substance (vitamin E and/or Super CD Serum) to the palm over and near the lump on the palm of the hand. Then DMSO directly over that same area . Allow to penetrate the skin for full benefit (takes only about 5 minutes); even though the area might still be wet the ability of DMSO to penetrate and carry other substances into the tissue is used up rapidly and is generally gone after the first few minutes.
When using DMSO for the first few times, it is not unusual to almost immediately experience a slight temporary and pleasant warmth or tingle (maybe lasting 30 seconds) where it has been applied. This is the response of the subcutaneous fat layer of the skin to the presence of the DMSO. It gets into your tissue so fast, the reaction is almost immediate!
Dupuytrens Contracture Connection
DMSO used alone demonstrates ability to soften the fibrous hardening of scleroderma, as well as similar fibrous tissue diseases, and stretch tissue needed during plastic surgery. While scleroderma is not Dupuytrens contracture or Peyronie’s disease , they both share enough similar collagen and soft tissue abnormalities to make it reasonable to connect the benefits of one problem to the other.
| ● DOUBLE IMPORTANCE OF DMSO ●1. DMSO has its own therapeutic properties, probably related to its sulfur content, that make it a valuable addition to any therapy program for Dupuytrens contracture. Used alone, it can soften many types of dense fibrous tissues.
2. DMSO carries other therapies into the tissue when they are combined on the skin. Therefore, vitamin E or copper will be driven in deeper and faster into the tissue where the Dupuytrens contraction nodules and cords are located. It is said that DMSO makes other therapies work better.
DMSO has a second strong Dupuytrens contracture connection by virtue of its ability to quickly carry – or as some say, “drive” – other therapies into the deep tissue layers for additional therapeutic benefit.
This double-duty action of DMSO has twice the potential benefit in a broad base Dupuytrens contracture program. If you are going to use vitamin E or copper in your plan, then you really should strongly consider including DMSO just so that the vitamin E and copper can penetrate deeper into the tissue for maximum potential benefit.
DMSO Product Recommendation
The doctors of PDI and DCI wanted to use a DMSO product that contained several synergistic products that could be helpful for DC. They soon learned that the discoverer of DMSO, Stanley Jacobs, MD, has been using a special formula of DMSO, vitamin E, methyl salicylate and urea for his own patients with great success. To make it easy and economical to apply, he made the formula into a gel formulation. Dr. Jacobs called his special DMSO formula DUSA-SAL Gel. When used twice daily it can be effective, and when combined in a larger therapy plan such as described by DCI the results can be just that much better. This particular product, Dusa-Sal Gel, was selected for use by DCI because of the encouraging reports and research behind each therapy. Our opinion is that this combination is a good way to get as much additional therapy into the local area of the lesion area as possible. We think you will not find a more effective, pure and safe DMSO product than Dusa-Sal Gel anywhere.
|DMSO is a solvent that will combine with another substance that is on the skin. When combined like this, both the DMSO and the other substance will be taken deeper and more quickly into the tissue. This combination of two or more therapies increases their effectiveness in treating your PD, in a process known as synergy.
The DMSO product fromDCI, called Dusa-Sal DMSO Gel, is a unique preparation made by Stanley Jacob’s Laboratory that gives you just one more advantage to bring an extra layer of therapy down to the PD scar.
By combining Callisto vitamin E oil, or Super CP Copper serum, with a layer of Dusa-Sal DMSO Gel over the scar area, you receive not only the benefit that each is taken deeper and faster into the tissue, but the DMSO has its own therapeutic advantages as well.
Check out Callisto OIL or Super CD Serum in other parts of this website to learn more about how these products can be used in putting together your PD therapy program, along with Dusa-Sal DMSO Gel.
By now you know the philosophy of DCI is to treat the hand contracture aggressively with as many different therapies as possible, for maximum therapeutic potential. Remember the DCI treatment philosophy is a lot like ganging up on your problem, “USE EVERY GOOD RESOURCE YOU CAN FIND, ALL AT THE SAME TIME, FOR AS LONG AS IT TAKES TO START SEEING RESULTS, THEN CONTINUE UNTIL YOUR BODY HEALS TO THE BEST OF ITS ABILITY.” We advocate approaching the contracted hand tissue very aggressively with very conservative measures. To do less than that is to take a grave risk with your hands that could result in a failure that no one wants to endure. Using a DMSO product that already contains vitamin E, methyl salicylate and urea, and taking that to drive even more vitamin E and copper in the form of Super CP Serum into the tissue is an excellent way to put that philosophy into action.
Dusa-Sal DMSO Gel comes in a shatterproof polyethylene bottle with a handy dispenser spout for ease of application.
For ideas and suggestions putting DMSO and other goodies into a treatment plan, click Create a Dupuytrens Treatment Plan.
Want to learn more technical information about DMSO?
The sister organization for the Dupuytrens Contracture Institute (DCI) is the Peyronie’s Disease Institute (PDI). There are many statistical and pathophysiological similarities between these two conditions, that the same group of doctors who created PDI have also developed DCI. Many men who have Peyronie’s disease note that their Dupuytrens contracture also improves. Therefore, there appears to be a natural confluence of interest between these two problems. What can be said for one problem can be said of the other, especially in terms of treatment..
|Why Buy from DCI?
1. Service DCI offers email support and assistance for the products and services we provide. We provide experience and interest in helping you with your problem. DCI is here to help you with questions about the products we sell. This is an extremely valuable service the others cannot possibly match.
2. Quality and Quantity Repairing the hand contractures is such an important mission. It is critical you use a high quality and quantity of nutrients. We have done the hard part selecting good companies and products. Buy with confidence.
3. Value DCI has a competitive pricing structure of which we are proud. We doubt you can find better products that deliver the quality and quantity for the prices we have set.
4. Convenience The longer you take to start treating your hand, the longer and more difficult treatment becomes, and the likelihood of success deteriorates. Everything you need is here, right now, in one place.
1. Lopez, D.A. Willims, R.M. Miehlke, M. Enzymes: The Fountain of Life: Neville Press, Inc. Charleston, SC. 1994. ISBN: 1-884303-00-5
2. Hermann Von Wimpffen, H. Pecher, M.O. Enzymes: A drug of the future. Ecomed: AG & Co. www.ecomed.de ISBN: 3-609-51280-6
3. Liu BY, Song HY. [Molecular cloning and expression of Nattokinase gene in Bacillus subtilis] Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 May;34(3):338-40. [Article in Chinese] Department of Molecular Genetics, School of Medicine, Fudan University, Shanghai 200032, China. firstname.lastname@example.org
4. Urano T, Ihara H, Umemura K, Suzuki Y, Oike M, Akita S, Tsukamoto Y, Suzuki I, Takada A. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001 Jul 6;276(27):24690-6. Department of Physiology, Hamamatsu University School of Medicine, 3600, Handa-cho, Hamamatsu, 431-3192, Japan.
5. Chang CT, Fan MH, Kuo FC, Sung HY. Potent fibrinolytic enzyme from a mutant of Bacillus subtilis IMR-NK1.J Agric Food Chem. 2000 Aug;48(8):3210-6. Department of Food and Nutrition, Providence University, Shalu, Taiwan, Republic of China.
6. Kim W, Choi K, Kim Y, Park H, Choi J, Lee Y, Oh H, Kwon I, Lee S. Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK 11-4 screened from Chungkook-Jang.Appl Environ Microbiol. 1996 Jul;62(7):2482-8. Department of Biotechnology, Institute of R & D, Yangpyung-Dong, Youngdeungpo-Gu, Seoul, (South) Korea.
7. Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat.Biol Pharm Bull. 1995 Oct;18(10):1387-91. Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan.
8. Fujita M, Hong K, Ito Y, Misawa S, Takeuchi N, Kariya K, Nishimuro S. Transport of nattokinase across the rat intestinal tract.Biol Pharm Bull.1995 Sep;18(9):1194-6. Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan.
9. Fujita M, Nomura K, Hong K, Ito Y, Asada A, Nishimuro S. Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1340-7. Biotechnology Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan.
10. Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery.Life Sci. 2003 Jul 25;73(10):1289-98. Dept of Pharmacology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu City, Shizuoka 431-3192, Japan.
11. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T, Umemura K. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003 Mar;19(3):261-4. Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan.
12. Tetsuya Hayashi, Chieko Takahashi, Yuji KikuchasdfgsdfasdfzxcvzxcvbzxcvxzCvzxcvzxcvzxcvzxcvzxcvxzv Japan Functional Food Research Association, Department of Physiological Chemistry, Kurashiki University of Science and the Arts, Kurashiki, Okayama 712-8505, Japan Received May 6, 1998; Accepted October 5, 1998
14 Ozawa, K. (1994). Effect of natto bacillus on the intestinal microsystem. In “Basic and Clinical Aspects of Japanese Traditional Food Natto,” Sumi, H. Japan Technology Transfer Association, Tokyo, pp. 113-118.
15. Sumi, H, Sasaki, K. Oral administration of urokinase. 17th Int. Congr. Hematology, Paris, abstr. p.327, 1978.
16 Sumi, H. Toki, N. Sasaki, K. Robbins, K. Oral administration of urokinase. Thrombi. Res. 20:711-714, 1980.
17. H.Sumi,H.Hamada, ,H.Tsushima,H. Mihara and H.Muraki. A novel fibrinolytic enzyme(nattokinase)in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet Department of Physiology, Miyazaki Medical College, Miyazaki 889-16(Japan), Department of Fundamental Natural Science, Okayama University of Science,Okayama 700(Japan),and Department of Fermentation Technology, Faculty of Engineering, Yamanashi University, Kofu 400(Japan), 23 June 1986
18. H. Sumi, H. Hamada, H. Mihara, K. Nakanishi*, H. Hiratani*. Fibrinolytic Effect of the Japanese Traditional Food “Natto” (Nattokinase) Dept. of Physiology, Miyazaki Med. College, Miyazaki, Japan and Biochemistry Research Labo*. of JCR Pharmaceuticals Co., Ltd., Kobe, Japan
Thromb. Haemostas 62: 549, 1989
19. Hiroyuki Sumi, Hiroki Hamada, Koichiro Nakanishi, Hajime Hiratani. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinase. Department of Physiology, Miyazaki Medical College, Miyazaki, Japan; Department of Biochemistry, Oklahoma State University, Okla., USA; Biochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan
20. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
26. Esch PM, Gerngross H, Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). Fortschr Med. 1989;107(4):67-8, 71-2.
27. Brewer Science Library website. 1999.
28. Panagariya A, Sharma AK. A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome. J Assoc Physicians India. 1999 Dec;47(12):1170-2. Comment in: J Assoc Physicians India. 2000 Nov;48(11):1130 PMID: 11310402 Dept. of Neurology, SMS Medical College and Hospital, Jaipur.
29. Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Nakai Y. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica. 1984;3(8):526-30.
30. Selan L, Berlutti F, Passariello C, Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Chemother. 1993 Dec;37(12):2618-21 Istituto di Microbiologia, Facolta di Farmacia, Universita La Sapienza, Rome, Italy.
31. Merten HA, Muller K, Drubel F, Halling F [Volumetric verification of edema protection with Serrapeptase after third molar osteotomy] Dtsch Z Mund Kiefer Gesichtschir. 1991 Jul-Aug;15(4):302-5. [Article in German] Zentrum Zahn-, Mund-, Kieferheilkunde der Universitat Gottingen.
32. Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res. 1990 Sep-Oct;18(5):379-88.Institute of Clinical Otorhinolaryngology, University of Naples, Italy.
33..Esch PM, Gerngross H, Fabian A. [Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase– a prospective study] Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2.[Article in German]
34. J. Ethnopharmacol, (1988) Feb-Mar; 22(2): 191
35. J. Protein Chem, (1995) Jan; 14(1): 41
36. Med. Sci. Sports Exerc., (1992) Jan; 24(1): 20
37. Nippon Yakurigaku Zasshi, (1979) Apr 20; 75(3): 227
39. Alt Med Rev 1996;1(4):243-257)